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[DOI] [PMC free article] [PubMed] [Google Scholar] 171.Reilly AM, Zhou S, Panigrahi SK, Yan S, Conley JM, Sheets PL, et al

When you eat a meal, nutrients in the gut trigger L cells to release GLP-1 into the bloodstream

The administration of unacylated, acylated, and PEGylated versions of this co-agonist dose-dependently reduced body weight, food intake, and fat mass and improved glycemic control and insulin sensitivity in rodent models of obesity and diabetes with greater efficacy than equimolar doses of GLP-1R agonist comparators exendin-4 and liraglutide [77]

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