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This appetite modulation occurs through both peripheral mechanisms (slowed gastric emptying) and central mechanisms (direct effects on hypothalamic appetite centers)

PMID: 40445127.

Mechanistically, osteocalcin signaling has been linked to the G proteincoupled receptor GPRC6A, providing a plausible pathway through which bone-derived signals influence pancreatic -cells, adipocytes, and Leydig cells

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Severe depression or active suicidal thoughts The MHRA, FDA, and EMA have reviewed the evidence and found no causal link between GLP-1 medications and suicidal thoughts or behaviour