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$225.00 Retatrutide (LY3437943) is a synthetic triple receptor co-agonist targeting the glucose-dependent insulinotropic polypeptide receptor (GIPR), glucagon-like peptide-1 receptor (GLP-1R), and glucagon receptor (GCGR) simultaneously the first compound in this mechanistic class to be characterised in clinical research

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Implications for Glucagon Family Receptor Poly-Agonists: GLP-1R Agonism Is Sine Qua Non Over the past few years, novel class B1 GPCR poly-ligands, i.e., compounds that bind more than one receptor simultaneously, have joined the ranks of the classic GLP-1RAs (GLP-1R mono-agonists), such as exenatide, liraglutide, semaglutide, dulaglutide, etc

Differences in trial design, participant populations, treatment duration, and endpoints mean that direct numerical comparisons between retatrutide Phase 2 data and semaglutide Phase 3 data are hypothesis-generating, not definitive