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Research is in the works

It can indicate peptide aggregation (clumping of denatured peptide molecules), bacterial contamination, or incompatible diluent
Hydration and electrolytes reduced food and fluid intake plus GI symptoms make dehydration a real risk

They degrade when exposed to heat, light, agitation, and time

What matters most is finding the dose that works best for you balancing comfort, results, and your personal health goals