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PLoS One 10:e0119034

Waistlines shrink by up to 11 centimetres on tirzepatide and CagriSema, half that on the older drugs

For a comprehensive comparison of these approaches, see the phentermine vs semaglutide analysis

Saunders, MD , obesity medicine specialist and co-founder of Intellihealth, "semaglutide, and all anti-obesity medications, are FDA-approved for long-term weight management because obesity is a chronic disease, just like hypertension and type 2 diabetes." Understanding side effects in that context matters: these are medications designed for long-term use, not quick fixes, and tolerating the adjustment period is part of the treatment