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Semaglutide (Ozempic, Wegovy, Rybelsus) : Available as once-weekly injection (0.52.0 mg for diabetes

Mechanisms by which adiponectin reverses high fat diet-induced insulin resistance in mice

These may include: Bloating and abdominal distension Flatulence and changes in bowel habit Mild abdominal discomfort or cramping Temporary changes in stool consistency These effects typically resolve within one to two weeks as the gut microbiome adjusts

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The medications also improved a wide range of liver markers, including liver stiffness