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For example, a methylene-linked oxetane increased potency 100-fold relative to the methyl substituent of 5 , leading to the identification of PF-06882961, which is a full agonist (EC 50 = 13 nM) in the CS cAMP assay (Fig

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Confounding factors It is important to first note that the majority of articles that were assessed which provided insight into patient demographics reported patients with confounding factors for retained gastric contents and aspiration (Ushakumari and Sladen 2024