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Unlocking melatonins potential: evidence from observational studies and trials The use of melatonin in older adults is increasing over time
(2021) published the pivotal STEP 1 trial in the New England Journal of Medicine, demonstrating that once-weekly subcutaneous semaglutide 2.4mg produced a mean weight reduction of 14.9% from baseline over 68 weeks in adults with overweight or obesity (BMI 27 kg/m) without diabetes
Participants also showed improved cardiovascular markers, suggesting metabolic benefits beyond the scale
Studies show semaglutide produces significant reductions in visceral fat, often disproportionate to total weight loss
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