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Semaglutide is eliminated primarily through peptide degradation and glomerular filtration, not hepatic metabolism, which means it does not compete with HRT for liver enzyme systems like cytochrome P450

Increased nausea, vomiting, early fullness even with small meals, bloating, and abdominal discomfort signal possible intolerance

Individual results varied significantly, with some participants losing over 20 percent and others losing less than 10 percent

Pausing or stopping the medication is rarely necessary, and is typically only considered if the shedding is severe or persistent