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This requires a comprehensive assessment of the patients clinical characteristics, such as the duration of diabetes, presence of comorbidities, body mass index, and response to previous treatments

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Assays, biomarkers, and phenotypic endpoints Biochemical and transcriptional readouts ERR target-gene panels spanning fatty-acid uptake/-oxidation (Cpt1b, Acadl/Acadm), OXPHOS (Ndufs, Uqcrc, Cox), TCA (Cs, Idh), and mitochondrial biogenesis (Ppargc1a, Tfam) provide proximal pharmacodynamic evidence of receptor engagement

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Phase 3 LIVERAGE trials ongoing for MASH with fibrosis