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Retatrutide works through simultaneous activation of three metabolic receptors: GLP-1 (which reduces appetite and improves insulin secretion), GIP (which enhances insulin sensitivity and influences fat storage), and glucagon (which increases energy expenditure and promotes hepatic fat oxidation)

Electroacupuncture demonstrated similar findings, relieving pain hypersensitivity in rats with spared nerve injury [32]

These symptoms typically emerge within the first few weeks of treatment or following dose increases

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In comparison with the animals in the control group, rats treated with 3 and 10 mg/kg of rimonabant had an increase in O 2 consumption of 18% and 49%, respectively, after 3 h