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The allowance for investigators to use all available information (for example, concomitant medication) to assess glycemic category was primarily included to account for scenarios in which glucose-lowering medications were initiated during the trial that would confound glycemic category assessment if based purely on fasting plasma glucose or HbA 1c levels (for example, if a patient developed diabetes during the study and received a glucose-lowering drug that resulted in their glucose level being below the American Diabetes Association threshold for type 2 diabetes diagnosis)

In this trial, many participants lost about 8-10% of their body weight, which is a good result for long-term weight loss

Nyenwe EA, Loganathan RS, Blum S, Ezuteh DO, Erani DM, Wan JY, Palace MR, Kitabchi AE

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Tesamorelin arrived later and was engineered for a different purpose entirely: a durable, degradation-resistant GHRH analog aimed at the metabolic problem of visceral fat accumulation in people with HIV on antiretroviral therapy