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Side effects , primarily gastrointestinal, are dose-dependent and often diminish with continued use at each dose level

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However, differences in study subjects and experimental designs, especially the heterogeneity of the gut microbiota itself, have made it difficult to study the modulatory effects of metformin on the gut microbiota

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Injection of contaminated medication could result in local injection site infections

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However, these two are not exactly the same

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KFFs 2025 employer survey found 18% of large employers explicitly excluded obesity-indication GLP-1s, while another 22% required prior authorization with BMI and behavioral-program documentation

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