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The decreased risk of heart failure associated with SGLT-2 inhibitors may be imparted by their haemodynamic effects on the heart, such as reduced intravascular volume, improved arterial elasticity, and decreased cardiac preload and afterload.4041 Concerning their renoprotective effects, SGLT-2 inhibitors ameliorate hyperfiltration in the proximal tubules, which reduces intraglomerular pressure.42 Thus, the decreased cardiorenal risk associated with the combined use of GLP-1 receptor agonists and SGLT-2 inhibitors may be attributed to an additive effect, achieved by the distinct mechanisms and sites of action for these different drug classes

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Obesity and weight loss in idiopathic intracranial hypertension: a narrative review

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Due to the metabolic regulatory function of GLP-1RAs, they have also been considered for the treatment of other diseases such as obesity, liver disease and other metabolic dysfunction diseases (22)

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General strategies: Follow the prescribed dose titration schedule carefully

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The rapidness of weight loss on GLP-1 therapy can have visible costs

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