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This is particularly relevant in probiotic interventions for bloating, where transit normalization is a key mechanism

Even after initial adjustment, starting with small amounts of alcohol (one drink or less) and consuming food alongside it can help minimize gastrointestinal distress

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In the landmark SURMOUNT-1 trial, participants on the highest dose lost an average of 22.5% of their body weight over 72 weeks, but that loss accumulated steadily over time rather than all at once