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Glucagon-like peptide-1 receptor agonists and risk of suicidality among patients with type 2 diabetes: active comparator, new user cohort study

237 The therapeutic effects of the amino salicylic acid class drug sulfalazine, 238 the antibiotics azithromycin and buspirone, 239 the opioid agonist human opiorphin, 240 the PDE5 inhibitor sildenafil 241 and many other commonly used clinical drugs in UC are attributed to the inhibition of the NFB pathway, which inhibits the expression of inflammatory cytokines and the infiltration of inflammatory cells, alleviating intestinal epithelial damage

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Based on sphingolipid biochemical pathways, sphingosine (So) and ceramide (Cer) can interconvert, and ceramide is further modified to become sphingomyelin (SM) or glucosylceramide (CerG1)