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(Another similar study in individuals with obesity but without T2D showed mean total weight loss of 16 to 22.5% after 72 weeks of treatment with tirzepatide 5-15 mg weekly.) Adverse events observed are mostly mild to moderate, transient gastrointestinal symptoms [69]

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Medical Reasons Behind Weight Loss Resistance on GLP-1s Beyond genetics and adaptation, several medical conditions can cause or contribute to semaglutide plateaus

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