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The IMCOSI trial demonstrated approximately 20% weight loss with the combination versus 16% with semaglutide alone over 48 weeks, though discontinuation rates were higher due to side effects

It typically appears as a subtle tingling that many people dismiss

It should be noted that these findings do not imply that DPP-4 inhibitors are harmful in any way or that GLP-1 drugs are definitely beneficial for brain health. Kornelius also explained that tirzepatide, a dual GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptor agonist, was not included in the study because it became available after the study period began

For example, GLP-1R/GIPR dual agonists have demonstrated superior glucose-lowering and weight-loss effects in the treatment of diabetes and obesity