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Insulin resistance: the link between obesity and cardiovascular disease
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Other studies have claimed that peripheral GLP-1 might bind to GLP-1R on the vagal afferent neurons, mainly located in portal circulation, and generate electrical signals to the brain, as was demonstrated in vagotomized rodent models in which GLP-1 did not reduce feeding [58,79,80]
J., Gotze, J
This effect is thought to be mediated by increasing natriuresis (35) and vasorelaxation in the renal vasculature (36)
