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Abstract Purpose of Review The glucagon-like peptide 1 (GLP-1) receptor agonists (RAs) liraglutide and semaglutide, and the dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) RA tirzepatide are approved for the treatment of overweight and obesity

Multiple randomized controlled trials including the SUSTAIN series demonstrate that GLP-1 therapy improves HOMA-IR (a measure of insulin resistance) and fasting insulin levels independent of weight loss alone

For patients with hypothyroidism and weight-loss resistance, this personalized data can clarify whether semaglutide, tirzepatide, or a dual-compound approach offers the best chance of success

Patients with these conditions require careful evaluation by their provider before initiating therapy, as they may be at increased the risk for gastrointestinal adverse effects or complications