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Mayo Clinic notes that approximately 25% to 40% of weight lost during GLP-1 therapy may come from lean mass which includes water, organs, bone, connective tissue, and skeletal muscle

However, surgery is certainly often a better long-term option for patients who do not want the expense or side-effect protocol of ongoing medications

Adoption remained modest until recent years as GLP-1 drug claims rose from 6.9 percent in 2023 to 10.5 percent in 2025

With these mixed results things remain unclear but more research will help us better understand how to use GLP-1RAs off-label for depression and anxiety effectively

doi: 10.1016/j.physbeh.2017.02.039