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Starting Dose: 2.5 mg SC every week for 4 weeks initially

Jardiance also met the trials secondary endpoint, showing a 14% reduction in the risk of first and recurrent hospitalization compared to placebo, a result that was deemed significant

This leads to decreased caloric intake, which is the primary driver of weight loss

Each protocol outlines the study rationale and design following the HARmonized Protocol Template to Enhance Reproducibility (HARPER), a structured framework for transparent and reproducible observational study design 44

GLP-1 drugs can have significant side effects, especially gastrointestinal issues related to constipation or nausea