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Without adequate protein intake and resistance training, a significant share of the weight lost on a GLP-1 will be lean mass rather than fat particularly concerning for older adults where sarcopenia is already a risk

This implies that GLP-1RAs may contribute to the treatment of immune dysregulation disorders, including lupus erythematosus and dermatomyositis [2]

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The FDA guidance clarifies that this exemption exists to ensure patients don't go without necessary medication during a supply disruption