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In clinical trials, participants lost an average of 15% to over 20% of their body weightnumbers previously seen only with bariatric surgery

Abbreviations AE Adverse event BMI Body mass index BP Blood pressure CI Confidence interval CV Cardiovascular CVOT Cardiovascular outcome trial DBP Diastolic blood pressure ETD Estimated treatment difference GIP Glucose-dependent insulinotropic polypeptide GLP-1 RA Glucagon-like peptide-1 receptor agonist HbA1c Glycated haemoglobin A1c MACE-4 Major adverse cardiovascular events proAND Pro-atrial natriuretic peptide SBP Systolic blood pressure T2D Type 2 diabetes WL-D Weight-loss dependent WL-IND Weight-loss independent Author contributions HP contributed to the conception of the work