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In contrast, substitution of C-terminal GLP-1 residues with corresponding glucagon residues decreases GLP-1R binding and maintains low GCGR-binding affinities, whereas replacement of, for example, the last three C-terminal residues of glucagon (Met 33 , Asn 34 , and Thr 35 ) with the corresponding GLP-1 residues (Val 33 , Lys 34 , and Gly 35 ) and an additional C-terminal GLP-1 residue (Arg 36 ) increases GLP-1R binding with affinity for GCGR remaining moderate

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Its important for families to understand that GLP-1 medications are not a quick fix for weight loss and should never replace healthy eating and exercise habits

10.1042/CS20171299 61