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LEAP-2 (Liver-expressed antimicrobial peptide 2) has been characterized as an endogenous competitive antagonist of ghrelin and proposed as a potential therapeutic target for obesity (128, 129)

Glucagon like peptide 1 receptor agonists in the treatment of obesity

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The niacinamide-containing tirzepatide formulations discussed earlier are partly motivated by this logic, since niacinamide is a NAD+ precursor

doi: 10.1111/dom.16660
