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From 4663 identified articles, 6 met the inclusion criteria, but only one was a randomized controlled trial

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Therefore, although DPP-4 inhibitors have attractive clinical features, the benefits that might be expected from GLP-1 signaling may be undermined by their actions to enhance SDF-1.

Why the question is not "animal or alternative" but "what does each model actually measure?" Stefano Gaburro, PhD The Wrong Question Dominates the Debate The pharmaceutical industry is infatuated with GLP-1 receptor agonists