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New England Journal of Medicine, 387(3), 205216

Time to Results: Noticeable Appetite Reduction: GLP-1s (semaglutide, tirzepatide): 1-2 weeks Phentermine: 1-3 days Phentermine-topiramate: 1-2 weeks Naltrexone-bupropion: 4-8 weeks Orlistat: Doesnt reduce appetite Measurable Weight Loss: Tirzepatide: 5-8% by week 20, 15-22% by week 72 Semaglutide: 5-7% by week 20, 10-15% by week 68 Phentermine-topiramate: 5-6% by week 28 Others: 3-5% by week 24-28 GLP-1s produce steady, sustained weight loss over 16-20 months

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This supports the hypothesis, as mentioned earlier, that GLP1based therapies may act protectively in the context of pancreatic cancer, especially in individuals with type 2 diabetes, rather than having an adverse effect

*Compounded medications are not FDA-approved and are not reviewed by the FDA for safety, effectiveness, or quality