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This trend is largely attributed to shifts in diet and lifestyle, such as increased sedentary behavior and higher consumption of ultra-processed foods 1

It also had a positive effect on body weight, with participants on IcoSema losing almost 8 pounds compared to those taking basal-bolus insulin who gained roughly 7 pounds

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Similar to WT albumin, both QMP variants demonstrated strict pH-dependent binding to FcRn, with rapid dissociation from the immobilized receptor upon injection of a pH 7.4 buffer (Supplementary Fig