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If you lose 30 or 50 pounds, your face is going to change, he said

Doing something is significantly better than doing nothing, regardless of which approach you choose
The persistent magnitudes of these interventions were quantified and varied by more than 4-fold, but even the intensive calorie restriction intervention corresponded to a persistent effect to cut energy intake by ~ 800 kcal/d over the two-year simulations

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That is a fundamental biochemical reality
