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10.1007/s00429-014-0714-z Summary Keywords GLP-1, obesity, diabetes, CNS, insulin Citation Heppner KM and Perez-Tilve D (2015) GLP-1 based therapeutics: simultaneously combating T2DM and obesity
Strategies for weight loss with GLP-1s: For those considering or currently using GLP-1 medications, here are several strategies that can enhance their effectiveness while minimizing side effects

Repeatedly injecting in the same location can lead to lipohypertrophy, a condition characterized by lumpy, thickened areas of fatty tissue that can impair medication absorption and lead to unpredictable blood glucose levels

With antiamyloid antibodies Leqembi (lecanemab) and Kisunla (donanemab) now FDAapproved for early Alzheimers, attention is turning to combination strategies that address multiple disease pathways