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It exists mainly as GLP-1 (736) amide and GLP-1 (737), both of which are rapidly degraded by the enzyme dipeptidyl peptidase-4 (DPP-4) into the inactive metabolite GLP-1 (936), giving the active form a plasma half-life of only 12 min (14, 15)

According to the FDA approval announcement, Zepbound (tirzepatide) represents a breakthrough in obesity treatment as the first and only FDA-approved weight loss medication that targets two distinct hormone receptors simultaneously

You can also explore whether the triple comparison including retatrutide gives you broader context on where these medications stand in the larger landscape

However, long-term studies are needed to evaluate weight loss durability and the potential need for continuous therapy

This leads to a more manageable appetite, which can support weight loss over time