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Additionally, we highlight the gaps for further studies in clinical applications of GLP-1 RAs in aging-related diseases

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Various GLP-1RAs have been demonstrated to have significant benefits in in vitro and in vivo models of neurodegenerative diseases through modulating a variety of pathogenic mechanisms, including neuroinflammation, autophagy, mitochondrial dysfunction, and the abnormal phosphorylation of pathognomonic proteins

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The basic steps are