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Finally, we demonstrate that in mice, both the efficacy and tolerability of GLP1R agonists vary with the phase of the estrous cycle, being highest during proestrus (when estrogen levels peak) and lowest in diestrus (low estrogen levels)

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**Functional Screening:** * The 10,000 designed GLP-1RAs underwent virtual screening based on stability, efficacy, and diversity criteria, which narrowed down the candidates to 60