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Adults with Overweight & Comorbidities: Individuals with a BMI of 27 kg/m or higher who also have at least one weight-related medical condition, such as hypertension (high blood pressure), type 2 diabetes, or dyslipidemia (high cholesterol)

The medication is administered as a once-weekly subcutaneous injection with doses titrated from 2.5 mg up to 15 mg

Researchers concerned that a slow start will delay efficacy should note that the 8 mg sweet spot is reached by week 9 regardless, and the gastrointestinal tolerance built in weeks 18 translates to better adherence and longer-term retention

During this adjustment period, some individuals report: Mild tiredness Lower energy Feeling off for several days These symptoms may improve over time

Gut dysbiosis is often linked with metabolic diseases such as obesity, insulin resistance, and T2DM and usually characterized by profoundly impaired microbial diversity and function [8]