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[DOI] [PubMed] [Google Scholar] 63.Gier B, Matveyenko AV, Kirakossian D, Dawson D, Dry SM, Butler PC

Pramlintide is an amylin analogue licensed for type 1 diabetes in the US but currently very few people are treated with it [4], and the risk of severe hypoglycaemia remains a barrier to its approval in the UK and Europe [5]

It also allows patients to be treated with the same dignity as people with other diseases

(2) Advantages Over Synthetics : Natural agonists often exhibit fewer gastrointestinal side effects and additional benefits (e.g., anti-inflammatory, lipid-lowering), though their efficacy and half-life are inferior to drugs like semaglutide

For this reason, GLP-1R agonists have been considered in the setting of PD
