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At the level used in this study it is not expected that long term consumption might induce a cumulative toxic effect on kidney or liver associated with the anti-nutrient compounds that are originally present in the leaves, such as saponins, tannins, terpenes or alkaloids [36]
If no drop appears, repeat until you see one

This can cause an increase in urination

It also slows down the digestive process and the speed at which food moves through the stomach, leading to a decreased appetite

These results suggest there is no excess cardiovascular risk with tirzepatide and are consistent with the improvements of numerous surrogate markers of cardiovascular health, including weight reduction, glycemic control with less hypoglycemia, blood pressure reduction, and improvements in the lipid profile