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Adding GIP long considered inactive showed powerful results

For astrocytes, GLP-1R activation prevents conversion to neurotoxic A1 phenotypes by interrupting microglia-derived IL-1/TNF-/C1q signaling [24,47,48], thereby promoting amyloid- clearance in Alzheimer's disease models [48] and pathogenic -synuclein in PD models [47]

As additional generic versions of Saxenda launch in the coming years, generic prices will likely decrease further.

The American Journal of Clinical Nutrition

Clinical trials for Wegovy and Zepbound, for example, have shown that users can lose an average of 15% and 20% of their body weight for 68 weeks