glp 1 agonist review article A new by Clifford J. Rosen, MD, and Julie R. Ingelfinger, MD, describes a new generation of treatment with GLP-1 receptor agonists for persons with obesity with or without diabetes or Glucagon-like peptide-1 receptor agonists and
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Hemodynamic advantages include enhanced control of afferent and efferent arterioles, mitigating hyperfiltration typical of early diabetic kidney disease

At therapeutic doses, GLP-1 drugs cross the blood-brain barrier and dampen dopamine signaling in the brains core reward center, making addictive substances less rewarding