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Furthermore, since the instability of Ala 2 is caused by degradation of DPP-4, Ala 2 may not need to be changed if the peptide is fused with albumin or Fc domain (discussed later) for long-term activity, which creates a steric hindrance to prevent the enzyme from getting close

They also demonstrated that infusions of GLP-1 in humans inhibited appetite and food intake, actions subsequently exploited in the clinic to treat obesity (40)

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Research indicates that GLP-1 medications can be used safely for extended periods, making them a viable option for long-term management of weight and metabolic health