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et al., 2024

Introduction: Semaglutide is a medication that has gained significant attention in recent years due to its remarkable efficacy in the treatment of type 2 diabetes and obesity

That raises the question of whether and how GLP-1R agonists, which were initially developed for use in the rest of the body, make their way into the brain

It has no ring structures similar to stimulants, no alkaloid backbone resembling opioids, no diazepine structure resembling benzodiazepines, and no cannabinoid chemistry resembling THC metabolites

Likewise, SGLT-2is may favor a eubiotic state, which is associated with better renal and metabolic outcomes