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Fatigue: A significant drop in calorie intake can lead to tiredness as the body adapts to using fat stores for fuel

These medicines, including liraglutide, albiglutide, dulaglutide, and semaglutide, were synthesised using strategic changes of the human GLP-1 molecule to diminish its vulnerability to DPP-4 breakdown

Some individuals (7% of those on Retatrutide compared to 1% on placebo) experienced skin sensitivity, but these cases were not serious

However, like other diabetes medications, they are not as effective as insulin at lowering blood sugar