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Summary Together, these findings demonstrate that elevated glucose results in actin polymerization that impedes both phases of biphasic insulin secretion, and that GLP-1 can restore glucose sensitivity and promote insulin release by correcting errors in actin dynamics at both phases

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Because SNAC protects semaglutide from pH-dependent degradation and the consumption of food leads to an increase in gastric pH, the effect of food and water on systemic semaglutide exposure was investigated

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