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Semaglutide (Wegovy, Ozempic and Rybelsus): risk of Non-arteritic Anterior Ischemic Optic Neuropathy (NAION)

10.1210/me.2005-0187

The second meta-analysis in 77,485 people from 28 randomized clinical trials showed that in people with type 2 diabetes, overweight, and obesity, treatment with GLP-1 receptor agonists was associated with a significant reduction of 14% in the relative risk, while separate medications, semaglutide, liraglutide, and dulaglutide, were associated with a reduction in the relative risk of 18%, 14%, and 18% for overall respiratory disease

It felt almost surreal to put an injector against my leg and have happen in 48 hours what decades of intervention could not accomplish, she says

While semaglutide pharmacokinetics are not significantly altered in patients with hepatic impairment, the medication has not been extensively studied in patients with severe hepatic dysfunction