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TABLE 2 Overview of GLP-1R agonist efficacy and safety in major clinical trials

Many patients experience great outcomes even without intensive workouts, though staying active can enhance results

Common side effects Headache Lightheadedness Drowsiness Constipation Diarrhea Fatigue Serious side effects Allergic reaction (hives, swelling, breathing difficulty) Blurred or temporary vision loss Increased risk of heart rhythm problems Serotonin syndrome (when combined with other serotonergic drugs): agitation, rapid heart rate, fever, tremor, seizures Abnormal heart rhythm (QT prolongation): chest pain, dizziness, fainting, especially with electrolyte imbalances Masked signs of bowel obstruction after surgery or chemotherapy Risk in phenylketonuria with ODTs (contains aspartame) Warnings and precautions Avoid if allergic to ondansetron or other 5-HT3 antagonists Do not combine with apomorphine (risk of severe hypotension) Discuss history of long QT syndrome, heart failure, slow heart rate, liver disease, or digestive blockage Review all prescription, OTC medications, and supplements for interactions Sources Ondansetron (Rx)

9 The effects can last from four to eight hours, depending on the dosage and form you're taking

Weight loss, achieved through a combination of diet, exercise, and lifestyle changes, can help improve GLP-1 levels and insulin sensitivity