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Similar to our results, some studies [21, 22] also indicated that GLP-1 receptor agonists had a positive effect on the heart and enhanced cardiac function
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In the SUSTAIN trials, semaglutide-treated patients achieved mean weight reductions of 10-15% of baseline body weight, with some reaching 20%+ loss at higher doses

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10.1186/s13098-015-0095-3 53