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Risk of bias: all four RCTs were rated low risk by RoB2 (with some concerns for open-label outcome ascertainment in three trials, a domain-specific issue that does not alter the overall RoB2 category from low)

If GLP-1 medication helped you achieve significant weight loss but left your face looking hollow, tired, or older than you expected, you are not alone

In recent years, new drugs for the treatment of type 2 diabetes (T2D) have been proposed, including glucagon-like peptide 1 (GLP-1) agonists or sodiumglucose cotransporter 2 (SGLT2) inhibitors and dipeptidyl peptidase-4 (DPP-4) inhibitors

Important Notes

The overall safety profile appears favorable, with serious adverse events being relatively rare and consistent with the broader GLP-1 receptor agonist class