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In addition to acting on neuronal cells, GLP-1R agonists also exert effects on microglia and astrocytes through cAMP/PKA signaling pathway

Nevertheless, the consistency of preclinical findings has fueled optimism that GLP-1based therapies may ultimately find uses far beyond diabetes and obesity

Notably, an improvement in HbA1c of up to 0.8% was also reported in those receiving survodutide, suggesting that the glycaemic benefits due to GLP-1 receptor agonism are maintained with survodutide despite also having glucagon receptor agonism

Considering that some of the GLP-1R agonists also decrease body weight, these have received approval for the treatment of obesity in humans [for a review, see Srivastava and Apovian (2018)]

FDA-approved semaglutide medications include Wegovy and Ozempic