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This can be linked to a significant reduction of serine palmitoyl transferase (SPT) protein levels and the downregulation of the ceramide-synthesis enzymes ceramide synthase 5 ( CERS5 ) and delta(4)-desaturase as well as sphingolipid 1 ( DEGS1 ) expression at both messenger-RNA and protein levels

Furthermore, these therapies have been shown to reduce the activation of microglial cells, key immune cells that play a significant role in triggering chronic pain in the central nervous system [36]

Together, these mechanisms produce a meaningful reduction in appetite and caloric intake

This includes people who never filled their initial prescription and those who filled a GLP-1 prescription but stopped refilling at some point throughout the year