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Others taper off after reaching their goal, though research from the SURMOUNT-4 trial shows that patients who stop treatment typically regain a substantial portion of the weight they lost

We will monitor your progress to ensure that all medications are working together to support your health in the best way possible

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Quick Comparison Feature CagriSema Retatrutide Development owner Novo Nordisk Eli Lilly Core strategy Combination therapy Single-molecule multi-agonist Pathways Amylin + GLP-1 GIP + GLP-1 + glucagon Main components Cagrilintide + semaglutide Retatrutide (LY3437943) 2026 status Phase 3 / regulatory-watch candidate Phase 3 TRIUMPH program Best-fit research question Can amylin extend GLP-1 results